“For this part, we’re just going to crouch in the corner of the deck. This forces the program to render Moriarty into the wardrobe which we locked in chapter 3. From there we can easily carry the wardrobe (ignore his screaming) all the way to Reichenbach Falls and toss him over. This triggers the alternate ending which is 38 seconds shorter”
Starts with rapid (~10^2ms) reversible engagement of ubiquitinated substrate, followed by slower (~1ms) insertion of the target protein C-terminus that triggers rapid proteasome cap rearrangement to engage deubiquitinase. Sequential deubiquitinase proceed rapidly compared to first. Proteolysis of the naked chain is limited by rate of unfolding, otherwise turns over very quickly.
Excellent talk from Prof Martin (Berkeley) to start day three of #PS32, deconvoluting how the 26S proteasome actually works through some kinetic analysis that warms this chemist's heart.
@bgcarlisle this one's for you
This afternoon I'm learning about CRISPR/Cas9 at #ps32!
Biophysics of the p53 tumour suppressor. Accessible healthcare in post-industrial USA. Higher- and med-ed. MD/PhD candidate at SUNY Upstate, Syracuse NY.
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