Drug dev; Cussing 

Oh fuck

:doi: doi.org/10.1016/S1473-3099(20)

This AI recommended Sunitinib + erlotinib for Covid-19?

I uhhh know a thing or two about sunitinib's development

Carlisle, B., et al. β€œBenefit, Risk, and Outcomes in Drug Development: A Systematic Review of Sunitinib.” JNCI 108, no. 1 (November 7, 2015): djv292–djv292. doi.org/10.1093/jnci/djv292.

And I can tell you right now that this is a bad idea

And I am about 10 times more sceptical about baricitinib now

Show thread

Today in "bad news about AI in health care" 

> Report: AI Company Leaks Over 2.5M Medical Records

> The leaked data relates to car accidents and includes names, insurance records, medical diagnosis notes, and payment records.

uk.pcmag.com/encryption/128228

Tomorrow night (2020 Aug 4) at 2000 UTC (2200 in Berlin, 1600 in Montreal) I will be doing my presentation entitled:

Clinical agnosticism and when trials say β€œmaybe”

In which I describe the ethical issues that result from inadequate hand-off between exploratory and confirmatory testing in clinical trials

:blobpats: πŸ’Š πŸ’‰

Clinical research interrupted by Covid-19 

I estimate that over 600k patients have been enrolled in clinical trials that were terminated, suspended or withdrawn due to Covid-19

covid19.bgcarlisle.com/publish

Parkinson's research ethics 

> Experimental Parkinson’s treatment draws ethics scrutiny with wealthy donor selected as first patient

> The problem here isn’t that Lopez received a transplant that thousands of other Parkinson’s patients wish they could try, but that a massive research effort was launched on his behalf because he paid for it.

geneticliteracyproject.org/202

On clinical research that has been stopped due to Covid-19 

> Among trials that were terminated, suspended or withdrawn citing Covid-19 as the reason, 505 (40%) included language in the β€œwhy stopped?” field that explicitly indicated an intention to start the study again after the pandemic ends. Among trials in the comparator arm taken from two years prior, 124 (9.4%) were started again within 1 year of the date when they were first stopped.

covid19.bgcarlisle.com/publish

Covid-19 and research waste 

There are 14 interventional trials testing Covid-19 indications that have been terminated, suspended or withdrawn since 2019-12-01. These included 6 trials (43%) that were stopped with reasons citing an inability to accrue sufficient patients, or a coordination issue, such as another project that is too similar. These trials had a combined anticipated enrollment of 1124 patients and an actual enrollment of 237 patients.

covid19.bgcarlisle.com/publish

Covid-19 research 

Weird milestone today in my project on clinical trials that stopped because of Covid-19

I identified a few trials that appeared to have stopped because of Covid-19

But in fact they were stopping because there weren't *enough* Covid-19 patients at their facility

So I did a search to double-check, and found 13 trials testing vaccines/therapies for Covid-19, 8 of which were stopped for reasons relating to accrual/coordination

Covid-19 research 

Paper from my former supervisor among others

"Ethics of controlled human infection to study COVID-19" by Shah et al. Science, 2020. :OpenAccess:

:doi: dx.doi.org/10.1126/science.abc

Covid-19 

Clinical trials that were suspended, terminated or withdrawn between 2019-12-01 and 2020-05-01

Clinical trials that were stopped, citing Covid-19 as the reason are coloured green

For comparison, the second graph depicts the number of clinical trials that stopped between 2017-12-01 and 2018-05-01

Source: covid19.bgcarlisle.com

Covid-19; Clinical Trials 

Posted an early draft of my project on clinical trials that stopped due to Covid-19

covid19.bgcarlisle.com

For-profit genome sequencing grumble 

So what if there was a law

A law requiring every single member of your extended family to consent before a for-profit company can sequence your genome, and if even a single family member refuses or can't be contacted for any reason, the process cannot continue

Show more
Scholar Social

Scholar Social is a microblogging platform for researchers, grad students, librarians, archivists, undergrads, academically inclined high schoolers, educators of all levels, journal editors, research assistants, professors, administratorsβ€”anyone involved in academia who is willing to engage with others respectfully.