The research fairy 🧚‍♂️ 🌈 @bgcarlisle@scholar.social

I estimate that over 600k patients have been enrolled in clinical trials that were terminated, suspended or withdrawn due to Covid-19

https://covid19.bgcarlisle.com/published/full-report-2020-06-06.html

#ResearchEthics #Bioethics

> Experimental Parkinson’s treatment draws ethics scrutiny with wealthy donor selected as first patient

> The problem here isn’t that Lopez received a transplant that thousands of other Parkinson’s patients wish they could try, but that a massive research effort was launched on his behalf because he paid for it.

https://geneticliteracyproject.org/2020/05/27/experimental-parkinsons-treatment-draws-ethics-scrutiny-with-wealthy-donor-selected-as-first-patient/

#bioethics #ResearchEthics

> Among trials that were terminated, suspended or withdrawn citing Covid-19 as the reason, 505 (40%) included language in the “why stopped?” field that explicitly indicated an intention to start the study again after the pandemic ends. Among trials in the comparator arm taken from two years prior, 124 (9.4%) were started again within 1 year of the date when they were first stopped.

https://covid19.bgcarlisle.com/published/full-report-2020-05-20.html

#Bioethics #Covid19

There are 14 interventional trials testing Covid-19 indications that have been terminated, suspended or withdrawn since 2019-12-01. These included 6 trials (43%) that were stopped with reasons citing an inability to accrue sufficient patients, or a coordination issue, such as another project that is too similar. These trials had a combined anticipated enrollment of 1124 patients and an actual enrollment of 237 patients.

https://covid19.bgcarlisle.com/published/full-report-2020-05-13.html

#bioethics #Covid19

Weird milestone today in my project on clinical trials that stopped because of Covid-19

I identified a few trials that appeared to have stopped because of Covid-19

But in fact they were stopping because there weren't *enough* Covid-19 patients at their facility

So I did a search to double-check, and found 13 trials testing vaccines/therapies for Covid-19, 8 of which were stopped for reasons relating to accrual/coordination

#Bioethics #ClinicalTrials #Covid19

Paper from my former supervisor among others

"Ethics of controlled human infection to study COVID-19" by Shah et al. Science, 2020.

https://dx.doi.org/10.1126/science.abc1076

#bioethics

Clinical trials that were suspended, terminated or withdrawn between 2019-12-01 and 2020-05-01

Clinical trials that were stopped, citing Covid-19 as the reason are coloured green

For comparison, the second graph depicts the number of clinical trials that stopped between 2017-12-01 and 2018-05-01

Source: https://covid19.bgcarlisle.com

#bioethics

Posted an early draft of my project on clinical trials that stopped due to Covid-19

https://covid19.bgcarlisle.com

#bioethics

So what if there was a law

A law requiring every single member of your extended family to consent before a for-profit company can sequence your genome, and if even a single family member refuses or can't be contacted for any reason, the process cannot continue

#Bioethics #PatientData #InformedConsent

> Cyberattack exposes information of 15 million LifeLabs customers in B.C. and Ontario

https://www.cbc.ca/news/canada/british-columbia/lifelabs-cyberattack-15-million-1.5399577 #PatientData #Bioethics

> Scientists Dodge FDA to Offer a $1 Million Anti-Aging Treatment in Colombia

https://onezero.medium.com/scientists-dodge-fda-to-offer-a-1-million-anti-aging-treatment-in-colombia-38756dfb3ad1 #Bioethics #HumanResearch

> Do large pharma companies provide drug development innovation? Our analysis says no

https://www.statnews.com/2019/12/10/large-pharma-companies-provide-little-new-drug-development-innovation/ #DrugDevelopment #Bioethics

> Rethinking drug design in the artificial intelligence era

https://www.nature.com/articles/s41573-019-0050-3 #AI #DrugDevelopment #Bioethics

> Senators want answers about algorithms that provide black patients less healthcare

https://arstechnica.com/tech-policy/2019/12/senators-want-answers-about-algorithms-that-provide-black-patients-less-healthcare/ #Bioethics #Healthcare #AI

> Amazon lets doctors record your conversations and put them in your medical files

https://www.cnbc.com/2019/12/02/amazon-web-services-unveils-transcribe-medical-software.html

#Bioethics #PatientConsent #BigTech

> Google's secret cache of medical data includes names and full details of millions – whistleblower

https://www.theguardian.com/technology/2019/nov/12/google-medical-data-project-nightingale-secret-transfer-us-health-information #Bioethics

> “She Never Looks Back”: Inside Elizabeth Holmes’s Chilling Final Months at Theranos

https://www.vanityfair.com/news/2019/02/inside-elizabeth-holmess-final-months-at-theranos #Bioethics #Startups #Theranos

Clinical trial of Xeno-Skin (genetically engineered pig skin xenograft) for treatment of severe burns in humans

https://clinicaltrials.gov/ct2/show/NCT03695939 #Bioethics #ClinicalTrials

C.f. https://onezero.medium.com/surgeons-transplanted-pig-skin-onto-humans-for-the-first-time-607fc519eb56

A re-#introductions post!

I'm the research fairy, here to make your academic problems disappear! 🧚‍♂️ 🌈

Recent experimental medicine PhD graduate from McGill in #Bioethics. Research interests include: #ResearchEthics, #MetaResearch, #HumanResearch, #Oncology, #ClinicalTrials, #Epidemiology, #MachineLearning, #ArtificialIntelligence, #MoralEfficiency, #DrugDevelopment, #ClinicalAgnosticism, #ScientificValue

Expect a lot of posts about #StarTrek if you follow me, though

> Most pediatric approval documents are filed under the wrong date in the Drugs@FDA data files

https://blog.bgcarlisle.com/2019/07/18/most-pediatric-approval-documents-are-filed-under-the-wrong-date-in-the-drugsfda-data-files/ #bioethics