I'm happy to share the preprint for recent work led by myself and @StanInScience@twitter.com looking at the 3D genome in prostate cancer as it goes into peer review.

"Cis-Regulatory Element Hijacking by Structural Variants Overshadows Topological Changes in Primary Prostate Cancer" is available on bioRxiv, now.



We performed Hi-C sequencing in frozen prostate tumours, combined our data with other genetic, transcriptomic, and epigenetic data on the same tumours, and investigated how mutations in prostate cancer rewire the genome and affect gene expression genome-wide.

We hope that these biological and technical insights will enable better characterization of patient tumour samples and give more insight into the assaults to the genetic architecture in cancer

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